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pentobarbital will lower the extent or impact of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can minimize panobinostat ranges by ~70% and lead to cure failure.I